From another forum:
For the Linux users searching for comskip info:
Comskip: copy the comskip.exe and comskip.ini to wine "windows" directory structure: Example
/root/.wine/drive_c/windows
Now from shell prompt.. you type wine comskip test.mpg
It should work...
Or:
Create a comskip.exe file with "wine comskip $1" , and chmod 755 comskip.exe
Comskip runs on Linux with the same speed as under Windows.